This symposium will cover the current approaches to novel target selection in
drug discovery. The differentiation of drug candidates through on- and offtarget
mechanisms and pathways will be discussed. Methods for target validation,
mechanism clarifi cation, measuring or predicting tractability, effi cacy and safety will
be covered to show how a better understanding of these interacting effects can
allow the development of better quality Lead and Clinical Candidates.
drug discovery. The differentiation of drug candidates through on- and offtarget
mechanisms and pathways will be discussed. Methods for target validation,
mechanism clarifi cation, measuring or predicting tractability, effi cacy and safety will
be covered to show how a better understanding of these interacting effects can
allow the development of better quality Lead and Clinical Candidates.
